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Self-organization of synthetic cholesteryl oligoethyleneglycol glycosides in water.
Langmuir. 2009 Aug 18;25(16):9424-31
Authors: Faivre V, Bardonnet PL, Boullanger P, Amenitsch H, Ollivon M, Falson F
Lectin-sugar recognition systems are of interest in the pharmaceutical field, especially for the development of drug carriers, tailored for selective delivery. This paper deals with the anhydrous and aqueous self-organization properties of a synthetic cholesteryl oligoethyleneglycol glycoside with the aim of their incorporation in liposomes. Successive phases (lamellar, R3m, Im3m, micelles) have been described depending on water content and temperature. As a result of the presence of sugar residues and their hydration ability, this glycolipid shows a large range of packing parameter with increasing water content. However, because of oligoethyleneglycol spacer, a slight dehydration has been observed with increasing temperature from 20 to 60 degrees C.
PMID: 19627161 [PubMed - indexed for MEDLINE]
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