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Fabrication and characterization of pseudo-ceramide-based liposomal membranes.
Colloids Surf B Biointerfaces. 2009 Oct 15;73(2):207-11
Authors: Kim DH, An EJ, Kim J, Han SH, Kim JW, Oh SG, Suh KD, Cho EC
We present a facile and straightforward method to fabricate liposomal membranes with a significantly stable lamellar structure consisting of pseudo-ceramide, fatty acid, and cholesterol. Characterizing their membrane properties, in which we have used differential scanning calorimetry, X-ray diffraction, and FT-IR spectra, enables us to demonstrate that pseudo-ceramide with appropriate amounts of stearic acid and cholesterol can assemble to form a stable lamellar alpha-phase. Moreover, we show that cholesterol is indeed important and plays a role in controlling the melting entropy of lipid membranes, which is attributed to a disordered molecular packing, thus creating more flexible liposomal membranes. This approach to use pseudo-ceramide offers a useful means to fabricate a variety of biocompatible liposomes with controllable membrane properties, which enlarges their applicability in the field of drug delivery, dermatology, and cosmetics.
PMID: 19539450 [PubMed - indexed for MEDLINE]
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